Amoxicillin (Amoxil®, Polymox®, Trimox®)

Section 1.1

Midwives may independently prescribe, order and administer this drug.

Penicillin antibiotics act as a broad spectrum bactericidal against many gram-positive and gram-negative microorganisms. This is achieved through the inhibition of biosynthesis of cell wall mucopeptide.

Indications and Clinical Use:

For treatment of uncomplicated asymptomatic or symptomatic urinary tract infections (UTIs) in pregnancy and the postpartum caused by Enterococcus faecalis, Escherichia coli, or Proteus mirabilis.


Documented hypersensitivity or allergy to amoxicillin or to any other penicillin antibiotic.

Warnings and Precautions:

Reduces efficacy of oral contraceptives; adjust dose in renal impairment; may enhance chance of candidiasis. Prolonged use may result in fungal or bacterial superinfection, including C. difficile associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months post-antibiotic treatment.

Use with caution in asthmatic patients.

Breastfed infants may develop slightly looser stools than normal. Modification of bowel flora and allergic sensitization of the infant may occur.


Human Data Suggest Risk in 1st and 3rd Trimesters.


Category L1 – Compatible

Adverse Reactions:

Upset stomach, diarrhea, vomiting, vaginal infection and mild skin rash. The following should be reported to a medical practitioner immediately: severe skin rash, itching, hives, difficulty breathing or swallowing, wheezing, unusual bleeding or bruising, sore throat, painful mouth or throat sores, jaundice and diarrhea.

Dosage and Administration:

  • Asymptomatic bacteriuria (ASB):
    Amoxicillin (Amoxil®, Polymox®, Trimox®): 500 mg orally every 8 hours (tid) for 3 days
  • Acute cystitis:
    Amoxicillin (Amoxil®, Polymox®, Trimox®): 250-500 mg orally every 8 hours (tid) for 10 days

May be taken with food

Onset of Action:

Oral: Rapid; food does not interfere with absorption.


1-1.4 hours