Amoxicillin-Clavulanic Acid

Section 1.1

Midwives may independently prescribe, order and administer this drug.

Amoxicillin exerts bactericidal action against sensitive organisms through inhibition of biosynthesis of the bacterial cell wall mucopeptides. Clavulanic acid extends the spectrum of amoxicillin by inhibiting specific beta-lactamases.

Indications and Clinical Use:

For the treatment of lactational mastitis caused by beta-lactamase producing strains of Staphylococcus aureus.


Documented allergy to penicillin; history of hypersensitivity or penicillin or cephalosporin group of beta-lactams; if mononucleosis is suspected or confirmed; history of amoxicillin-clavulanic acid-associated jaundice/hepatic dysfunction.

Warnings and Precautions:

Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis. Use in caution with anyone with phenylketonuria. May reduce the efficacy of combined oral contraceptives.


Category B


Category L1 – Limited Data – Compatible

Dosage and Administration:

Mastitis: 500-875mg PO q12 hours (BID) for 7-10 days.

Taking with food may minimize gastrointestinal distress

Half Life:

1 hour


Renal excretion: urine (25%-40% as unchanged drug)