Section 1.1

Midwives may independently prescribe, order and administer this drug.

First generation cephalosporin antibiotic. Cefazolin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins, thus inhibiting cell wall biosynthesis.

Indications and Clinical Use:

If allergic to Penicillin, and at low risk for anaphylaxis, intravenous Cefazolin may be administered.


Hypersensitivity to cefazolin sodium, any component of the formulation, or other cephalosporins

Warnings and Precautions:

Use with caution in patients with a history of penicillin allergy.
Use with caution in patients with renal impairment.
Use with caution in patients with a history of seizure disorder.
Breastfed infants may develop slightly looser stools than normal.




Category L1 – Compatible

Adverse Reactions:

Fever, seizure, rash, pruritus, Stevens-Johnson syndrome, diarrhea, nausea, vomiting, abdominal cramps, colitis and oral candidiasis

Dosage and Administration:

IV: 2 g followed by 1 g every 8 hours until delivery.

Onset of Action:

IV: Peak serum concentrations occur immediately once administration is complete and within 0.5-2 hours.


90-150 minutes


Urine (80% to 100% as unchanged drug)