Section 1.1

Midwives may independently prescribe, order and administer this drug.

First generation cephalosporin antibiotic. Cefazolin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins, thus inhibiting cell wall biosynthesis.

Indications and Clinical Use:

If allergic to penicillin, and at low risk for anaphylaxis, intravenous cefazolin may be administered for intrapartum chemoprophylaxis against GBS infection.


Hypersensitivity to cefazolin sodium, any component of the formulation, or other cephalosporins

Warnings and Precautions:

Use with caution in patients with a history of penicillin allergy, renal impairment and seizure disorder. Breastfed infants may develop slightly looser stools than normal.




Category L1 – Compatible

Adverse Reactions:

Fever, seizure, rash, pruritus, Stevens-Johnson syndrome, diarrhea, nausea, vomiting, abdominal cramps, colitis and oral candidiasis

Dosage and Administration:

IV: 2g followed by 1g q8 hours until delivery.

Onset of Action:

IV: Peak serum concentrations occur immediately once administration is complete and within 0.5-2 hours.


90-150 minutes


Urine (80% to 100% as unchanged drug)