Midwives may independently prescribe, order and administer this drug.
First generation cephalosporin antibiotic. Cefazolin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins, thus inhibiting cell wall biosynthesis.
Indications and Clinical Use:
If allergic to Penicillin, and at low risk for anaphylaxis, intravenous Cefazolin may be administered.
Hypersensitivity to cefazolin sodium, any component of the formulation, or other cephalosporins
Warnings and Precautions:
Use with caution in patients with a history of penicillin allergy.
Use with caution in patients with renal impairment.
Use with caution in patients with a history of seizure disorder.
Breastfed infants may develop slightly looser stools than normal.
Category L1 – Compatible
Fever, seizure, rash, pruritus, Stevens-Johnson syndrome, diarrhea, nausea, vomiting, abdominal cramps, colitis and oral candidiasis
Dosage and Administration:
IV: 2 g followed by 1 g every 8 hours until delivery.
Onset of Action:
IV: Peak serum concentrations occur immediately once administration is complete and within 0.5-2 hours.
Urine (80% to 100% as unchanged drug)