Cefazolin

Section 1.1

Midwives may independently prescribe, order and administer this drug.

First generation cephalosporin antibiotic. Cefazolin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins, thus inhibiting cell wall biosynthesis.

Indications and Clinical Use:

If allergic to Penicillin, and at low risk for anaphylaxis, intravenous Cefazolin may be administered.

Contraindications:

Hypersensitivity to cefazolin sodium, any component of the formulation, or other cephalosporins

Warnings and Precautions:

Use with caution in patients with a history of penicillin allergy.
Use with caution in patients with renal impairment.
Use with caution in patients with a history of seizure disorder.
Breastfed infants may develop slightly looser stools than normal.

Pregnancy:

Compatible

Lactation:

Category L1 – Compatible

Adverse Reactions:

Fever, seizure, rash, pruritus, Stevens-Johnson syndrome, diarrhea, nausea, vomiting, abdominal cramps, colitis and oral candidiasis

Dosage and Administration:

IV: 2 g followed by 1 g every 8 hours until delivery.

Onset of Action:

IV: Peak serum concentrations occur immediately once administration is complete and within 0.5-2 hours.

Half-life:

90-150 minutes

Elimination:

Urine (80% to 100% as unchanged drug)