Cefixime (Suprax®)

Section 1.1

Midwives may independently prescribe, order and administer this drug.

An oral antibiotic of the cephalosporin class, related to penicillin. This drug has an extended spectrum of activity including about 95% coverage of E. Coli, which is the most common organism causing UTI in pregnancy.

Indications and Clinical Use:

Used for the treatment of urinary tract infection in pregnancy (UTI). This drug should be considered as a second line for treatment of UTI in pregnancy due to concerns of developing resistance.

Contraindications:

Allergy to cephalosporin group of antibiotics

Warnings and Precautions:

Chance of cross-reactivity is low (around 3%) if the patient is penicillin sensitive, however do not use it for highly allergic (eg. anaphylactic) patients. Use with caution in patients with colitis.

Alteration of GI flora may occur, as with all antibiotics, see Probiotic Use with Antibiotics.

Pregnancy:

Compatible

Lactation:

Category L2 – Limited Data – Probably Compatible

Adverse Reactions:

Diarrhea, gas, loose stools, nausea and stomach upset.

Dosage and Administration:

The dose is 400 mg daily for 7 days.
Administer with food if GI upset occurs.

Onset of Action:

Time to peak, serum: 2-6 hours; delayed with food.

Half-life:

3-4 hours.