Cefixime

Section 1.1

Midwives may independently prescribe, order and administer this drug.

An oral antibiotic of the cephalosporin class, related to penicillin.

Indications and Clinical Use:

For use as a second line treatment of urinary tract infections in pregnancy and postpartum. Prescribe only when there is no alternative. This drug has an extended spectrum of activity including about 95% coverage of Escherichia coli.

Contraindications:

Allergy to cephalosporin group of antibiotics

Warnings and Precautions:

Chance of cross-reactivity is low (around 3%) if the patient is penicillin sensitive, however do not use it for highly allergic (e.g. anaphylactic) patients. Use with caution in patients with colitis.

Pregnancy:

Compatible

Lactation:

Category L2 – Limited Data – Probably Compatible

Adverse Reactions:

Diarrhea, gas, loose stools, nausea and stomach upset.

Dosage and Administration:

Cystitis: 400mg PO once daily (OD) for 7 days.

Onset of Action:

Time to peak, serum: 2-6 hours; delayed with food.

Half-life:

3-4 hours.