Cefixime (Suprax®) STI Treatment

STI Standards

Midwives may independently prescribe, order, and administer drugs in the community, hospital or other sites of midwifery practice to treat sexually transmitted infections for clients in case, as designated under specialized practice certification. Midwives without specialized practice certification in sexually transmitted infections management are required to refer their clients to an appropriate health care practitioner for treatment. 

(Suprax®) An oral antibiotic of the cephalosporin class, related to penicillin. This drug has an extended spectrum of activity including about 95% coverage of E. Coli, which is the most common organism causing UTI in pregnancy.

Indications and Clinical Use:

Used for the treatment of asymptomatic or symptomatic Neisseira Gonorrhea in pregnancy and the postpartum as a first line treatment and as a single dose. Also used for the treatment of UTI in pregnancy as a second line for treatment of UTI in pregnancy due to concerns of developing resistance.


Allergy to cephalosporin group of antibiotics.

Warnings and Precautions:

Chance of cross-reactivity is low (around 3%) if the patient is penicillin sensitive, however do not use it for highly allergic (eg. anaphylactic) patients. Use with caution in patients with colitis.

Alteration of GI flora may occur, as with all antibiotics, see Probiotic Use with Antibiotics.


Compatible – Limited human pregnancy data do not suggest embryo or fetal risk.


No Data – probably compatible.

Adverse Reactions:

Diarrhea, gas, loose stools, nausea, and stomach upset.

Dosage and Administration:

Neisseria Gonorrhea:
Cefexime: 800mg orally as a single dose.
Administer with food if GI upset occurs.

Onset of Action:

Time to peak, serum: 2-6 hours; delayed with food.

Duration of Action:

Half-life elimination: 3-4 hours.