Midwives may independently prescribe, order and administer this drug.
Cloxacillin is a penicillin-type antibiotic and is closely related to methicillin. It interferes with bacteria cell wall formation by weakening the cell wall, causing rupture and killing bacteria.
Indications and Clinical Use:
For the treatment of mastitis caused by susceptible strains of Staphylococcus aureus.
Hypersensitivity to cloxacillin. Any other penicillin allergy.
Warnings and Precautions:
Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months post-antibiotic treatment. Use with caution in patients with renal impairment; modify dosage in severe impairment. Breastfed infants may develop slightly looser stools than normal.
No (Limited) Human Data – Probably Compatible
Category L2 – Limited Data – Probably Compatible
Upset stomach, diarrhea, vomiting, vaginal infection and mild skin rash.
The following side effects should be reported to a medical practitioner immediately: severe skin rash, itching, hives, difficulty breathing or swallowing, wheezing, unusual bleeding or bruising, sore throat, painful mouth or throat sores, jaundice and diarrhea.
Dosage and Administration:
Mastitis: 500mg PO q6 hours (QID) for 5-7 days if the response is rapid and complete or 10-14 days as indicated.
Cloxacillin should be taken 1 hour before or 2 hours after meals with water. Serum levels are reduced by 50% with food intake.
Onset of Action:
Rapid onset, peak in about 1 hour.
Adults: 0.5-1.5 hours