Midwives may independently prescribe, order and administer this drug.
(Gravol®) is categorized in a class of drugs called antihistamines. Competes with histamine for H1-receptor sites on effector cells in the respiratory tract, gastrointestinal tract and blood vessels; blocks chemoreceptor trigger zones.
Indications and Clinical Use:
To counteract the side effects of nausea and vomiting. While it is considered safe, Gravol® may produce some sedation and as such, may be used for therapeutic rest during prodromal or early labour, particularly where anxiety is a factor.
Hypersensitivity or previous reactions to dimenhydrinate or any component of the formulation.
Warnings and Precautions:
Use with caution in patients with asthma, peptic ulcer, cardiac arrhythmias and thyroid dysfunction.
Category L2 – No Human Data – Probably Compatible
Palpitations, hypotension, confusion, nervousness, restlessness, headache, insomnia, tingling, heaviness and weakness of hands, vertigo, dizziness, blurred vision, nasal stuffiness, dryness of nose and throat, nausea, vomiting, diarrhea, constipation, dry mouth, tightness of chest and wheezing.
Dosage and Administration:
Usual Concentration: each mL contains 50 mg
50-100 mg PO every 4-6 hours, maximum dose 400 mg/day
25-50 mg IM, IV, every 4 hours, maximum dose 100 mg every 4 hours
25 mg IV should be administered slowly over 2 min
Dimenhydrinate in the injectable form is indicated when the oral or suppository form is impractical.
For severe nausea and vomiting in hospital setting, Gravol® may also be administered through the IV route.
Onset of Action:
20 to 30 minutes