Nystatin (Nilstat®, Mycostatin®)

Section 1.1

Midwives may independently prescribe, order and administer this drug.

Anti-fungal agent which binds to sterols in fungal cell membrane, changing the cell wall permeability.

Indications and Clinical Use:

For the treatment of Candidiasis, particularly of the mouth (thrush) and intestines of infants and children. A less potent antifungal than clotrimazole or miconazole for vaginal candida.

Contraindications:

Hypersensitivity to Nystatin or any component of the formulation

Pregnancy:

Compatible

Lactation:

Category L1 – Compatible

Adverse Reactions:

Diarrhea, stomach pain, nausea and vomiting.

Dosage and Administration:

Oral drops: 100,000 units (1 mL) every 6-8 hours (tid – qid). Continue therapy for at least 48 hours after clinical cure to prevent relapse.
Also available in topical and vaginal formats but is less effective than other antifungals.

Onset of Action:

24 – 72 hours