Phytonadione (Vitamin K1)

Revised December 11, 2017

Section 1.1

Midwives may independently prescribe, order and administer this drug.

Vitamin K1) is a fat-soluble vitamin administered to the newborn shortly after birth to reduce the likelihood of vitamin K deficiency bleeding (VKDB), formerly known as hemorrhagic disease of the newborn (HDN).  The intramuscular (IM) route is the most effective route compared to oral or parental routes in reducing the incidence of VKDB, and is currently considered to be the standard of care. Should parents refuse intramuscular administration, oral administration of the IM preparation as per the dosage regime below should be recommended as part of an informed choice discussion.

Dosage and Administration:

IM route:

1 mg IM within six (6) hours of birth if birth weight is greater 1500 grams

0.5 mg IM within six (6) hours of birth if birth weight is less than 1500 grams

Oral route:

2 mg orally within six (6) hours of birth, 2 mg orally at 2-4 weeks of age and 2 mg orally at 6-8 weeks of age.

If the infant regurgitates any of the oral doses within one hour of administration, the oral dose should be repeated.