Midwives may independently prescribe, order and administer this drug.
Amoxicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis.
Indications and Clinical Use:
For the treatment of uncomplicated urinary tract infections (UTIs) in pregnancy and postpartum caused by susceptible strains of Enterococcus faecalis, Escherichia coli, or Klebsiella pneumoniae.
Documented hypersensitivity or allergy to amoxicillin, other beta-lactam antibacterial drugs or any components of their formulation.
Warnings and Precautions:
Reduces efficacy of oral contraceptives; adjust dose in renal impairment; may enhance chance of candidiasis. Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months post-antibiotic treatment. Use with caution in asthmatic patients. Breastfed infants may develop slightly looser stools than normal. Modification of bowel flora and allergic sensitization of the infant may occur.
Category B: animal studies fail to reveal risk.
Category L1 – Compatible
Upset stomach, diarrhea, vomiting, vaginal infection and mild skin rash. The following should be reported to a medical practitioner immediately: severe skin rash, itching, hives, difficulty breathing or swallowing, wheezing, unusual bleeding or bruising, sore throat, painful mouth or throat sores, jaundice and diarrhea.
Dosage and Administration:
Asymptomatic bacteriuria: 250-500mg PO q8 hours (TID) for 3 days
Cystitis: 250-500mg PO q8 hours (TID) for 5-7 days
Onset of Action:
Oral: Rapid; food does not interfere with absorption.