Midwives may independently prescribe, order and administer this drug.
Inhibits mucopeptide synthesis of bacterial cell wall. Penicillin G is a bactericidal against penicillin susceptible microorganisms.
Indications and Clinical Use:
Intravenous Penicillin G is the antibiotic of choice for intrapartum chemophophylaxis.
History of a hypersensitivity reaction to any penicillin.
Warnings and Precautions:
Administer drug with caution to cephalosporin-sensitive patients due to possible cross-reactivity.
Use with caution in patients with histories of significant allergies and/or asthma.
Use with caution in patients with renal impairment and in patients with a history of seizure disorder.
Breastfed infants may develop slightly looser stools than normal.
Category L1 – Compatible
Anxiety, confusion, dizziness, tremors, nausea, vomiting and diaphoresis.
Dosage and Administration:
IV: 5 million units followed by 2.5 million units every 4 hours until delivery.
Onset of Action:
IV: Peak serum concentrations occur immediately once administration is complete and within 1 hour.
Excretion: Urine (58% to 85% as unchanged drug)
Urine (58% to 85% as unchanged drug)