Triamcinolone (Kenacomb®) – neomycin sulfate, nystatin, gramicidin

Section 1.1

(Kenacomb®) cream or ointment reduces inflammation, relieves pruritis and combats or prevents monilial and bacterial infections. The corticosteroid is absorbed through normal intact skin, with percutaneous absorption increased in the presence of skin irritation or inflammation. The antibacterial and antifungal agents are absorbed where the skin is inflamed.

Indications and Clinical Use:

Used as a topical treatment for candidiasis of the nipple, with or without secondary bacterial infection, as well as candidiasis-related diaper rash in the healthy newborn.


It should not be used on viral or tubercular lesions, or by anyone with a systemic viral infection or a history of allergy to any of the ingredients.

Warnings and Precautions:

If burning, itching, or local irritation increases with use, treatment should be discontinued. Kenacomb® is not recommended for use in pregnancy. While generally well tolerated, kenacomb® should not be used over large areas of the skin, particularly in the newborn, and is not intended for prolonged use to treat candidiasis of the nipple or candidiasis-related diaper rash.

If the condition has not improved within a week, physician consultation is indicated.


Triamcinolone – Human and Animal Data Suggest Risk
Neomycin – Human Data Suggest Low Risk
Nystatin – Compatible


Triamcinolone and Neomycin – Category L3 – No Data – Probably Compatible
Topical use to small area is not associated with problems
Nystatin – Category L1 – Compatible
Gramicidin – Category L3 – No Data – Probably Compatible

Adverse Reactions:

Contact dermatitis, dryness, pruritus and secondary skin infection.

Dosage and Administration:

Each gram contains 100,000 units nystatin, 2.5 mg neomycin base (as sulphate), 0.25 mg gramicidin, and 1.0 mg triamcinolone.
Apply a thin layer to affected areas 2-3 times/day.